The Explorers had a 4-1 lead before exploding for seven runs over the final three frames.
Ryan Donahue surrendered three hits and allowed one run over 3 1/3 innings to collect the win for La Salle.
Alex Farina took the loss, allowing two earned runs over four innings. He struck out two.
Joe Bennie hit his fourth home run of the season, a two-run shot in the eighth for the Explorers.
La Salle will face Penn next Tuesday in a semifinal contest of the Liberty Bell Classic.